Naturally occurring extended-spectrum cephalosporinases in Escherichia coli.
نویسندگان
چکیده
Genetic and functional characterization of the cephalosporinases produced by 65 clonally unrelated clinical Escherichia coli isolates revealed genetic diversity of the ampC genes and showed that Gln287, Cys287, Pro296, Leu298, and Phe350 substitutions were involved in extension of the hydrolysis spectrum to include ceftazidime and cefepime.
منابع مشابه
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1. Mammeri H, Eb F, Berkani A et al. Molecular characterization of AmpC-producing Escherichia coli clinical isolates recovered in a French hospital. J Antimicrob Chemother 2008; 61: 498–503. 2. Nordmann P, Mammeri H. Extended-spectrum cephalosporinases: structure, detection, and epidemiology. Future Microbiol 2007; 2: 297–307. 3. Mammeri H, Poirel L, Nordmann P. Extension of the hydrolysis spec...
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(EUCAST). http://www.srga.org/eucastwt/MICTAB/index.html. 4. Mammeri H, Poirel L, Fortineau N et al. Naturally occurring extended-spectrum cephalosporinases in Escherichia coli. Antimicrob Agents Chemother 2006; 50: 2573–6. 5. Mammeri H, Eb F, Berkani A et al. Molecular characterization of AmpC-producing Escherichia coli clinical isolates recovered in a French hospital. J Antimicrob Chemother 2...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 50 7 شماره
صفحات -
تاریخ انتشار 2006